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DC Field | Value | Language |
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dc.contributor.author | FADIPE, Labake Ajoke | - |
dc.contributor.author | Jimoh, Oladejo Tijani | - |
dc.contributor.author | Otache, S. A | - |
dc.contributor.author | Shuibu, D. T | - |
dc.date.accessioned | 2021-06-01T11:15:27Z | - |
dc.date.available | 2021-06-01T11:15:27Z | - |
dc.date.issued | 2011-12-30 | - |
dc.identifier.citation | FADIPE, A. L., Jimoh, T.O., Otache, S. A & Shuaib, D. T. (2011). Antibacterial efficacy of the pigmented and de-pigmented leaf extracts of Alstonia boonei Wild. International Journal of Applied Biological Research, 3 (2), 23−31 | en_US |
dc.identifier.uri | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/630 | - |
dc.description.abstract | This work was carried out to evaluate the antibacterial efficacy of pigmented and de-pigmented petroleum ether and methanolic extracts of Tridax procumbens (whole plant). Phytochemical screening of these extract using standard methods revealed that the pigmented and de-pigmented petroleum ether extract showed the strong presence of steroidal nucleus only, while the pigmented and de-pigmented methanol extracts revealed the presence of alkaloids, saponins, tannins, flavonoids, steroidal nucleus and cardiac glycosides. The in-vitro antibacterial assay of these extracts revealed that the de-pigmented methanol extract showed appreciable activity against all the test organisms at 100 mg/ml- a broad spectrum inhibitory effect that was quite similar to that produced by the standard drug, Tetracycline at 0.5 mg/ml against Gram positive Staphylococcus aureus and Bacillus subtilis and was slightly better against Gram negative Pseudomonas aeruginosa. The minimum inhibitory (MIC), minimum bactericidal (MBC) concentrations and MBC/MIC ratio of the active extract ranged between 12.5-100 mg/ml and 25-100 mg/ml and 1.00 and 2.00 respectively. Purification of the active extract by preparative thin layer chromatography gave rise to polar fractions that exhibited similar/slightly better inhibitory activities against the test organisms at 50 mg/ml than the crude de-pigmented methanolic extract at 100 mg/ml. MIC, MBC and MBC/MIC ratios of the active fractions ranged between 12.5-50 mg/ml and 25-50 mg/ml and 1.00 and 4.00 respectively. The above findings suggest that the de-pigmented methanol extract of A. booni might be a valuable source of antibacterial substance(s) for the treatment of diarrhea, typhoid fever, urinary and gastrointestinal infections. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Applied Biological Research, 3 (2), 23−31 | en_US |
dc.relation.ispartofseries | Volume 3;2 | - |
dc.subject | Alstonia boonet, leaf extracts; methanol; pigmented; de-pigmented; fractions; antibacterial | en_US |
dc.title | Antibacterial efficacy of the pigmented and de-pigmented leaf extracts of Alstonia boonei Wild | en_US |
dc.type | Article | en_US |
Appears in Collections: | Chemistry |
Files in This Item:
File | Description | Size | Format | |
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5th_paper[1].pdf | 2.5 MB | Adobe PDF | View/Open |
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