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http://repository.futminna.edu.ng:8080/jspui/handle/123456789/5955| Title: | Synthesis and Antimicrobial Activity of Schiff Bases Derived from 5-Chlorosalicylaldehyde with Substituted Aniline |
| Authors: | Salihu, Simon Olonkwoh Auta, Helen Shnada |
| Keywords: | 5-Chlorosalicyladehyde, Aniline, Antimicrobial, Activity. |
| Issue Date: | 9-Dec-2016 |
| Publisher: | Elixir |
| Citation: | Abidemi Iyewumi Oloyede-Akinsulere et al./ Elixir Appl. Chem. 101 (2016) 43578-42581 |
| Abstract: | Schiff bases (E)- 4- chloro-2- ((phenylimino) methyl) phenol, (E)- 4- chloro- 2- (((2-methoxyphenyl) imino) methyl) phenol, (E)- 4- chloro- 2-(((4-chlorophenyl) imino)methyl) phenol, (E)-4-chloro-2- (((5-chloro-2-methylphenyl) imino) methyl) phenol were synthesized from 5-chlorosalicylaldehyde and substituted aniline. The synthesized compounds were characterized by elemental analysis, IR, UV, 1H, and 13C NMR. The antibacterial studies revealed that the compounds exhibit broad spectrum antibacterial activity against Escheriochia coli, Klebsiella pneumonia, proteus mirabilis, Pseudomonas aeruginosa and Salmonella typhimurium. The antibacterial activities was affected by the substituent on the aniline part. |
| Description: | The authors appreciate the Organization of Women in Science in Developing World for the research fellowship granted to A.I. Oloyede-Akinsulere, to study in the Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia. They are grateful to Prof. Dr. M. A. Hapipah, Department Of Chemistry, niversity of Malaya for providing the NMR analyses and allowing the use of her laboratory for the research. They express their profound gratitude to Dr. Z.S. Ololade, of Department of Chemical Sciences, Bells University, Ota, Nigeria who helped with the antimicrobial analysis. Also, the authors acknowledge the management of Adeyemi College of Education, Ondo, Nigeria for granting Oloyede –Akinsulere, A.I a study leave. |
| URI: | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/5955 |
| ISSN: | 2229-712x |
| Appears in Collections: | Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Oloyed-Akinsulere & SALIHU_Synthesis and antimicrobial activity of Schiff base derived_.pdf | Article | 443.74 kB | Adobe PDF | View/Open |
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