Assessment of Testicular Recovery of Ethanolic Extracts of Calocybe Indica Following Cadmium Chloride-Induced Testicular Toxicity in Rats

Abstract

Occupational and environmental exposure to cadmium poses a harmful consequence inherent to its toxicity. In addition to harming target cells to varied degrees, it primarily affects the liver, kidney, and testes. It may be found in food, the atmosphere, and possibly even drinking water. In this study, the effect of the mushroom Calocybe indica (CLE) on rats’ testicular toxicity caused by cadmium chloride (CdCl2 ) is being evaluated. The six groups of experimental animals, each with five animals, were utilized. Groups B, C, D, E, and F received subcutaneous injections of (3 mg/kg CdCl2 ), while Group A served as the experiment’s control group. For 21 days, group C received an oral dose of 100 mg/kg of vitamin C. For 21 days, Groups D, E, and F received CLE treatments at doses of 200 mg/kg, 400 mg/kg, and 800 mg/kg respectively. It was evident that exposure to 3 mg/kg of cadmium chloride for three weeks resulted in substantial harm to the reproductive system. In this study, it has been established that administering the mushroom extract (Calocybe indica) to the rats induced with cadmium chloride testicular toxicity for three weeks resulted in to increase in antioxidant activity as well as a minor reduction in the toxicity of cadmium to the testicles