Please use this identifier to cite or link to this item:
http://repository.futminna.edu.ng:8080/jspui/handle/123456789/1715
Title: | Toxicological Evaluation of Bee Sting in Plasmodium berghei Infected Mice |
Authors: | Shittu, Oluwatosin Kudirat |
Keywords: | Malaria bee sting Plasmodium berghei enzyme activities |
Issue Date: | 24-Feb-2015 |
Publisher: | International Journal of Biochemistry Research and Review. |
Citation: | 35. Shittu OK and Rabiu I (2015). Toxicological Evaluation of Bee Sting in Plasmodium Berghei Infected Mice. International Journal of Biochemistry Research and Review. 6(4): 170 - 177 |
Series/Report no.: | 6(4);170 - 177 |
Abstract: | Aim: Based on the traditional and scientific claims of intra-dermal antiplasmodial activity of bee stings, its effect on liver and serum enzymes in Plasmodium berghei-infected mice were investigated. Methodology: Twenty albino mice were intra-peritoneally infected with P. berghei and divided into four animals per group. Group I was set up as negative control (parasitized untreated), group II as parasitized treated with 5 mg chloroquine/kg body weight, group III as suppressive treated, group IV as curative treated and group five as not parasitized not treated. Results: The results of serum alanine transaminase (ALT) and aspartate transaminase (AST) of the infected treated with chloroquine shows significant increase when compared to other experimental groups (p˂ 0.05). Whereas, there was increase in liver AST in group II, group III and group IV when compared to not parasitized not treated (p˂ 0.05). Also, there was significant decrease in liver ALT activity in all the experimental groups. The serum and liver gamma glutamyl transferase (GGT) showed no significant difference (p<0.05) in the curative and suppressive groups when compared to the standard drug (chloroquine). Whereas, parasitized not treated group shows significant increase (p<0.05) in the liver GGT and ALP when compared with other experimental groups. Therefore, these increases in specific activity of the parasitized untreated group might be due to infection. Conclusion: It can be concluded that bee sting have ameliorative effect against changes caused by P. berghei |
URI: | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/1715 |
ISSN: | 2231-086X |
Appears in Collections: | Biochemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Shittu642015IJBcRR160362.pdf | 363.13 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.