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DC Field | Value | Language |
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dc.contributor.author | Shittu, Oluwatosin Kudirat | - |
dc.date.accessioned | 2021-06-06T11:34:49Z | - |
dc.date.available | 2021-06-06T11:34:49Z | - |
dc.date.issued | 2015-02-24 | - |
dc.identifier.citation | 35. Shittu OK and Rabiu I (2015). Toxicological Evaluation of Bee Sting in Plasmodium Berghei Infected Mice. International Journal of Biochemistry Research and Review. 6(4): 170 - 177 | en_US |
dc.identifier.issn | 2231-086X | - |
dc.identifier.uri | http://repository.futminna.edu.ng:8080/jspui/handle/123456789/1715 | - |
dc.description.abstract | Aim: Based on the traditional and scientific claims of intra-dermal antiplasmodial activity of bee stings, its effect on liver and serum enzymes in Plasmodium berghei-infected mice were investigated. Methodology: Twenty albino mice were intra-peritoneally infected with P. berghei and divided into four animals per group. Group I was set up as negative control (parasitized untreated), group II as parasitized treated with 5 mg chloroquine/kg body weight, group III as suppressive treated, group IV as curative treated and group five as not parasitized not treated. Results: The results of serum alanine transaminase (ALT) and aspartate transaminase (AST) of the infected treated with chloroquine shows significant increase when compared to other experimental groups (p˂ 0.05). Whereas, there was increase in liver AST in group II, group III and group IV when compared to not parasitized not treated (p˂ 0.05). Also, there was significant decrease in liver ALT activity in all the experimental groups. The serum and liver gamma glutamyl transferase (GGT) showed no significant difference (p<0.05) in the curative and suppressive groups when compared to the standard drug (chloroquine). Whereas, parasitized not treated group shows significant increase (p<0.05) in the liver GGT and ALP when compared with other experimental groups. Therefore, these increases in specific activity of the parasitized untreated group might be due to infection. Conclusion: It can be concluded that bee sting have ameliorative effect against changes caused by P. berghei | en_US |
dc.description.sponsorship | The authors are grateful to the authorities of Tertiary Education Trust Fund University of Technology, Minna for the institutional based research grant provided to support the research work. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Biochemistry Research and Review. | en_US |
dc.relation.ispartofseries | 6(4);170 - 177 | - |
dc.subject | Malaria | en_US |
dc.subject | bee sting | en_US |
dc.subject | Plasmodium berghei | en_US |
dc.subject | enzyme activities | en_US |
dc.title | Toxicological Evaluation of Bee Sting in Plasmodium berghei Infected Mice | en_US |
dc.type | Article | en_US |
Appears in Collections: | Biochemistry |
Files in This Item:
File | Description | Size | Format | |
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Shittu642015IJBcRR160362.pdf | 363.13 kB | Adobe PDF | View/Open |
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