Preliminary studies on the antiplasmodial potential of aqueous and methanol extracts of eucalyptus camadulensis leaf

Abstract

Objective: The rising problem of resistance to the classical drugs like chloroquine and the nperowb laenmti mofa lraerciaru adgeesnctesn. cTeh iosf pmroajleacrti aw aafst edre tsriegantemde tnot ewxipthlo raer ttehme isainntiinp lassumggoedsita lt hpeo tneenetida lf oorf Eucalyptus camaldulensis leaf extracts. Methods: The antiplasmodial potential of the methanol manadla ariqau. eSowuiss se xatlrbaicntos mofi cEeu cwaelryep tiunstr acpaemraitdounleeanllsyis i n(lfeeacft)e wd ewreit he vpallausamteodd iiunm a bmeroguhseei m(NoKd6e5l) , oaf rpoadceknetd m caellalr ivao pluamraes it(e. The level of parasitemia, life span, variation in weight and percentage of extracts. Treatment% w PitChV t)h oef eixntfreaccttesd a at nddo ster elaetveedl sm oifc e were used to assess the efficacy commenced 100, 200 and 400mg/kg body weight 72 hours post infection for the test groups, while a standard antimalarial drug, Anertgeastuivnea tceo, nattr ao ld gorsoeu opf w50ams gl/ekfgt ubnodtrye awteeidg.h Rt wesaus latds:m inistered on the positive control group. The showed a significant decrease in parasitaemia Animals treated with the methanol extract with those treated with the aqueous extract whi(cph <s u0r.0v5iv),e adn fdo rs urvived for 29 days compared parasitemia. 19 days with a higher level of parasitaemia However, the control group treated with Artesunate showed a significantly lower methanol and( pa q<u e0o.0u5s) eaxntdr ascutsrv. ived for 34 days when compared with the groups treated with the treated groups was significanTtlhye lloewveerl of parasitemia, decrease in weight and %PCV in all group (P < 0.05) compared with the infected but untreated leaves (noef gative control) which survived for only 7 days. Conclusions: The methanol extract of the mankind.E