Somma, Samuel AbuAkinwande, N. I.Chado, U. D.2025-04-142019-06-10https://dx.doi.org/10.4314/ijs.v21i1.17http://repository.futminna.edu.ng:4000/handle/123456789/670In this paper a mathematical model of monkey pox virus transmission dynamics with two interacting host populations; humans and rodents is formulate. The quarantine class and public enlightenment campaign parameter are incorporated into human population as means of controlling the spread of the disease. The Disease Free Equilibrium (DFE) and Endemic Equilibrium (EE) are obtained. The basic reproduction number R 0 < h and R 0r 1 and R 1 < are computed and used for the analysis. The Disease Free Equilibrium (DFE) is analyzed for stability using Jacobian matrix techniques and Lyapunov function. Stability analysis shows that the DFE is stable if .enArticle