School of Life Sciences (SLS)

Permanent URI for this communityhttp://197.211.34.35:4000/handle/123456789/40

School of Life Sciences (SLS)

Browse

Author: search.filters.author.Abdulfatai, Ismail

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Cancer Chemotherapy: A Review Update of the Mechanisms of Action, Prospects and Associated Problems
    (BIOMED Natural and Applied Science, 2021) Aishatu, Mustapha; Abdulfatai, Ismail; Jonathan, Ibrahm; Dauda, Muhammed; Opeyemi, N. Hassan; Peter, I. Ugwunnaji; Eustace, B. Berinyuy
    Cancer is one of the leading causes of death in developed countries, responsible for about 25% of all deaths. On a yearly basis, 0.5% of the population is diagnosed with cancer. Treatment options include surgery, radiotherapy, and systemic therapies such as chemotherapy, endocrine therapy, and targeted agents. Conventional chemotherapeutical agents act by creating toxic effects on all dividing cells. The toxic byproducts of some chemotherapeutic drugs are deposited mainly in the liver producing hepatotoxicity, leading to many side-effects like loss of appetite, nausea, vomiting, diarrhea, abdominal cramps and constipation, anemia, fatigue, hyperthermia, loss of hair, etc. In this review update, the benefits and problems of chemotherapy have been highlighted and the mechanisms involved in cancer formation, groups of chemotherapeutic agents, as well as method of chemotherapeutic administration, have been discussed.
  • No Thumbnail Available
    Item
    In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana
    (Advance Research in Life Science, 2020-10) Simon, C. Mai lafiya; Sheridan, O. Kolawole; Abdulazeez, K. Adeniyi,; Bala, A. Muhammed; Abdulfatai, Ismail; Adenine, R. Alawode; Bashir, Lawal
    The harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepatoprotective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.