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    Bifurcation Analysis on the Mathematical Model of Measles Disease Dynamics
    (Horizon Research Publishing Co., Ltd., 2013-12) Samuel Abubakar; Ninuola Ifeoluwa Akinwande; Sirajo Abdulrahman; Festus Abiodun Oguntolu
    In this paper we proposed a Mathematical model of Measles disease dynamics. The Disease Free Equilibrium (DFE) state, Endemic Equilibrium (EE) states and the characteristic equation of the model were obtained. The condition for the stability of the Disease Free equilibrium state was obtained. We analyze the bifurcation of the Disease Free Equilibrium (DFE) and the result of the analysis was presented in a tabular form.
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    On the verification of existence of backward bifurcation for a mathematical model of cholera dynamics
    (African Journals Online, 2023-09-12) A. A. Ayoade; O. J. Peter; F. A. Oguntolu; C.Y. Ishola; S. Amadiegwu
    A cholera transmission model, which incorporates preventive measures, is studied qualitatively. The stability results together with the center manifold theory are used to investigate the existence of backward bifurcation for the model. The epidemiological consequence of backward bifurcation is that the disease may still persist in the population even when the classical requirement of the reproductive number being less than one is satisfied.
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    Mathematical Modeling of Polio Virus Infection Incorporating Immigration and Vaccination
    (Faculty of Physical Sciences, University of Ilorin, 2019-12-01) G. Bolarin; I. U. Omatola; A. Yusuf; C. E. Odo; F. A. Oguntolu; M. A. Philip
    A deterministic mathematical model for polio infection dynamics with emphasis on immigration and vaccination was formulated and analyzed. We derived the basic reproduction number, of the model formulated. The effective reproduction number was computed using the next generation matrix to enable a qualitative analysis to be carried out on the model. Also, the disease-free equilibrium and endemic equilibrium points were computed. On analyzing the equilibrium points, we found that the disease-free equilibrium point is locally asymptotically stable if and the condition for existence on an Endemic Equilibrium point was also established. More so, numerical simulations showed that vaccination coverage of about 75% would be enough to eradicate polio from the population.
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    Mathematical model for the control of lymphatic filariasis transmission dynamics
    (SCIK Publishing Corporation, 2021-02-23) Festus Abiodun Oguntolu; Gbolahan Bolarin; Olumuyiwa James Peter; Abdullah Idris Enagi; Kayode Oshinubi
    In this paper, a mathematical model for the transmission dynamics of lymphatic filariasis is presented by incorporating the infected without symptom, the infected with symptom and treatment compartments. The model is shown to have two equilibrium states: the disease-free equilibrium (DFE) and the endemic equilibrium states. An explicit formula for the effective reproduction number was obtained in terms of the demographic and epidemiological parameters of the model. Using the method of linearization, the disease-free equilibrium state was found to be locally asymptotically stable if the basic reproduction number is less than unity. By constructing a suitable Lyapunov function, the disease-free equilibrium state was found to be globally asymptotically stable. This means that lymphatic filariasis could be put under control in a population when the effective reproduction number is less than one. The endemic equilibrium state was found to be locally asymptotically stable. By constructing yet another Lyapunov function, the endemic equilibrium state was found to be globally asymptotically stable under certain conditions. Sensitivity analysis was carried out on the effective reproduction number, the most sensitive parameters were the treatment rate of human population and the infected rate of human population. Results from the simulation carried out showed that treatment level coverage of human population should target a success rate of 75% for LF to be under control in the population.
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    Modelling the impacts of media campaign and double dose vaccination in controlling COVID-19 in Nigeria
    (Elsevier BV, 2023-10) N.I. Akinwande; S.A. Somma; R.O. Olayiwola; T.T. Ashezua; R.I. Gweryina; F.A. Oguntolu; O.N. Abdurahman; F.S. Kaduna; T.P. Adajime; F.A. Kuta; S. Abdulrahman; A.I. Enagi; G.A. Bolarin; M.D. Shehu; A. Usman
    Corona virus disease (COVID-19) is a lethal disease that poses public health challenge in both developed and developing countries of the world. Owing to the recent ongoing clinical use of COVID-19 vaccines and non-compliance to COVID-19 health protocols, this study presents a deterministic model with an optimal control problem for assessing the community-level impact of media campaign and double-dose vaccination on the transmission and control of COVID-19. Detailed analysis of the model shows that, using the Lyapunov function theory and the theory of centre manifold, the dynamics of the model is determined essentially by the control reproduction number (Rmv). Consequently, the model undergoes the phenomenon of forward bifurcation in the absence of the double dose vaccination effects, where the global disease-free equilibrium is obtained whenever Rmv≤1. Numerical simulations of the model using data relevant to the transmission dynamics of the disease in Nigeria, show that, certain values of the basic reproduction number ((R0≥7)) may not prevent the spread of the pandemic even if 100% media compliance is achieved. Nevertheless, with assumed 75% (at R0=4)) media efficacy of double dose vaccination, the community herd immunity to the disease can be attained. Furthermore, Pontryagin's maximum principle was used for the analysis of the optimized model by which necessary conditions for optimal controls were obtained. In addition, the optimal simulation results reveal that, for situations where the cost of implementing the controls (media campaign and double dose vaccination) considered in this study is low, allocating resources to media campaign-only strategy is more effective than allocating them to a first-dose vaccination strategy. More so, as expected, the combined media campaign-double dose vaccination strategy yields a higher population-level impact than the media campaign-only strategy, double-dose vaccination strategy or media campaign-first dose vaccination strategy.