Journal Articles
Permanent URI for this communityhttp://197.211.34.35:4000/handle/123456789/1
Journal Articles
Browse
381 results
Search Results
Item Cancer Chemotherapy: A Review Update of the Mechanisms of Action, Prospects and Associated Problems(BIOMED Natural and Applied Science, 2021) Aishatu, Mustapha; Abdulfatai, Ismail; Jonathan, Ibrahm; Dauda, Muhammed; Opeyemi, N. Hassan; Peter, I. Ugwunnaji; Eustace, B. BerinyuyCancer is one of the leading causes of death in developed countries, responsible for about 25% of all deaths. On a yearly basis, 0.5% of the population is diagnosed with cancer. Treatment options include surgery, radiotherapy, and systemic therapies such as chemotherapy, endocrine therapy, and targeted agents. Conventional chemotherapeutical agents act by creating toxic effects on all dividing cells. The toxic byproducts of some chemotherapeutic drugs are deposited mainly in the liver producing hepatotoxicity, leading to many side-effects like loss of appetite, nausea, vomiting, diarrhea, abdominal cramps and constipation, anemia, fatigue, hyperthermia, loss of hair, etc. In this review update, the benefits and problems of chemotherapy have been highlighted and the mechanisms involved in cancer formation, groups of chemotherapeutic agents, as well as method of chemotherapeutic administration, have been discussed.Item Prevalence of protozoan parasites in some freshwater fishes of Dangana Lake Lapai, Niger State Nigeria(International Journal of Veterinary Sciences and Animal Husbandry 2020; 5(2): 13-16, 2020) Mohammed Yakubu Manbe; Adamu Kabir Mohammed; Ismail Abdulfatai; Umar Muaz; Kanki HussainiPrevalence of protozoan parasites in some freshwater fishes of Dangana Lake Lapai were studied. A total of 184 fish from four (4) species were examined for ecto-parasites in the lake which were Clarias gariepinus (55), Tilapia zilli (51), Oreochromis nilocticus (41), and Leptocypris nilocticus (37). The parts of the fish that were examined are gills, skin, and fins. In all, 5 different protozoan parasites were isolated from the fish samples examined. The overall prevalence of protozoan parasites in sampled fishes was 84.76%. The percentage incidence revealed that Clarias gariepinus recorded 23.36%, Tilapia zilli, 22.28%, Oreochromis nilocticus, 20.10%, and Leptocypris nilocticus and 19.02% incidence. Five (5) species of protozoan parasites were encountered namely Ichthyobodo sp Gyrodactylus sp. Trichodina sp Caprina sp. and Microsporideans sp. The study revealed high protozoan prevalence from the study areaItem Assessment of some physicochemical parameters of Moussa stream, Bida, Niger State Nigeria(Journal of Public Health and environmental Pollution, 2020-09) Mohammed, Y. M.; Arimoro, F. O.; Ayanwale, A. V.; Adamu, K. M.; Ismail, A.; Umar M.; Kanki, H.The physicochemical characteristics of Moussa stream were studied monthly from January to August 2017 using standard methods and procedure. The results from the stream showed that water Temperature (24.9-27.5 C), Depth (14.7-45.8cm), Flow velocity (0.14-0.23 m/s), pH (6.33-8.6), Dissolved oxygen (3.10- 10.00 mg/L), Biochemical oxygen demand (2.0-7.0 mg/L), Turbidity (61-285NTU), Conductivity (20-63 µ/cm), Alkalinity (8-30 mg/L), Nitrate (0.87-3.85 mg/L), Phosphate (0.31-1.01mg/L) and Sodium (0.9- 13.5mg/L). All the physicochemical parameters were within the maximum permissible limit except Dissolved Oxygen (3.1-10 mg/L). All the parameters showed no significant difference (p>0.05) among all the sampling stations except depth and flow velocity which differed significantly (p<0.05) among all the sampling stations. Similarly temperature, depth and flow velocity showed no significant difference among sampling season. pH, DO, BOD, turbidity conductivity alkalinity, Nitrate Phosphate and Sodium differed significantly among sampling seasons. The deteriorating water quality were implications of pollution stress caused by different anthropogenic activities.Item Continuous Professional Development Dissemination and Knowledge Addition for Building Construction Professionals Belonging to Built Environment Regulatory Bodies(International Journal of Engineering Management and Humanities (IJEMH), 2025) Alaezi, J. O.; Umbugala, M. D.; Mubarak, R. I.; Agidani, J.; Igwe, C. O.Item In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana(Advance Research in Life Science, 2020-10) Simon, C. Mai lafiya; Sheridan, O. Kolawole; Abdulazeez, K. Adeniyi,; Bala, A. Muhammed; Abdulfatai, Ismail; Adenine, R. Alawode; Bashir, LawalThe harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepatoprotective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.Item Evaluation of the Implementation of Automotive Mechatronic Programme in Vocational Enterprise Institutions in Nigeria(International Journal of Industrial Technology Education, Engineering, Science and Education (IJITESED), 2021) Igwe, C. O.; Abdulkadir, M.; Mustafa, A.; Nma, T. N.; Aliyu, T.; Nma, Y. A.The study was designed to evaluate the implementation of automotive mechatronics programme of the Vocational Enterprise Institutions (VEIs) in Nigeria. Two research questions and two null hypotheses guided the study. A descriptive survey research design was employed for the study. The study was conducted in three VEIs offering automotive mechatronics programme in FCT Abuja and Kaduna State. A total of 90 respondents comprising of 14 administrators 32 instructors and 44 technical staff drawn from the three National Board for Technical Education accredited Vocational Enterprise Institutions offering Automotive Mechatronics Programme in Federal Capital Territory, Abuja and Kaduna State was used as a total population for the study, A structured questionnaire titled: Automotive Mechatronics Programme Evaluation Implementation Questionnaire (AMPEIQ) developed by the researchers and validated by three experts from Industrial and Technology Education Department, Federal University of Technology, Minna was used for data collected for the study. The reliability coefficient of the instrument was 0.78 using Cronbach Alpha statistics. Statistical Package for Social Science (SPSS Version 23) was used for the data analysis. Mean, standard deviation, frequency and percentage were the statistical tools used for answering research questions while ANOVA Statistics was used to analyze the null hypotheses formulated for the study at 0.05 level of significant. The findings of the study revealed among others that: the available training equipment/facilities were rarely often used and most teaching methods needed for effective implementation of automotive mechatronics programme were rarely often used. Based on the findings it was recommended that: The VEIs in FCT Abuja and Kaduna State should adhere to the NBTE minimum requirement of training equipment/facilities for the implementation of the automotive mechatronics programmes, the available training equipment/facilities in the VEIs in FCT Abuja and Kaduna State should be effectively utilized for the implementation of the automotive mechatronics programmes, the automotive mechatronics instructors/technical staff of the VEIs in FCT Abuja and Kaduna State should be encourage to adopt wide range of teaching methods in teaching automotive mechatronics.Item Awareness and Engagement with Artificial Intelligence Technologies As Predictors of Undergraduates' Readiness in Building and Woodwork Technology for Construction Practices in Benue State.(Multidisciplinary Journal of Science and Technology Education, 2025) Nule, J. S.; Upwa, F. E.; Nwokolo-Ojo, J. O.; Tar, S.; Igwe, C. O.Industrial paternalism has been a significant factor influencing the development of Vocational and Technical Education (VTE) in Benue State. This study examined the impact, challenges and strategies of industrial paternalism on VTE using a population of 431 (97 academics and 334 non-academics) VTE graduates registered with Technical Education Practitioners Association of Nigeria (TEPAN). Krejcie and Morgan table was used to arrive at a sample size of 205 respondents. A stratified sampling technique was employed to ensure a representation across different groups. A researcher developed 15 item questionnaire was validated, subjected to reliability testing using the Cronbach’s Alpha reliability technique which yielded a reliability index of 0.87. Data collected was analyzed using mean and standard deviation to answer research questions while Inferential T-test was used to test the null hypotheses. The study revealed that industrial paternalism significantly impacts on VTE development in Benue State. The study recommended that: Government should review/update policies and increase funding that reflects current labour market demands and encourage industrial paternalism in Benue State, government and relevant stakeholders should adopt incentives and public awareness campaigns to improve paternalistic policies through tax breaks and government support and government at all levels should enhance collaboration between industries and educational institutions.Item Implementation of National Board for Technical Education Curriculum in Science and Colleges in Nigeria(Annals of Technology Education Practitioners Association of Nigeria (ATEPAN), 2025) Igwe, C. O.; Ibeneme, O. T.; Nwokolo-Ojo, J. O.; Nule, J. S.Item In-silico investigation of curcumin drug-likeness, gene-targets and prognostic relevance of the targets in panels of human cancer cohorts(GSC Biological and Pharmaceutical Sciences, 2021, 14(01), 037–046, 2021) David B Oshevire; Aishatu Mustapha; Blessing U. Alozieuwa; Hassana H. Badeggi; Abdulfatai Ismail; Opeyemi N. Hassan; Peter I Ugwunnaji; Jonathan Ibrahim; Bashir Lawal; Eustace B. BerinyuDespite advancements in diagnostic and standard treatment modalities, cancer survival rate remains disappointing globally. It has however, been recognized that exploring the therapeutic properties of secondary metabolite from natural products may alleviate the problems of drug resistance and toxicity that besiege the conventional therapies, and hence improve the overall prognosis of cancer patient. To this end curcumin, a polyphenolic natural compound has been widely studied for it anticancer activities in in vitro and in vivo models. Computational technology has significantly improved the success rate of drug discovery and development, hence, it has become a widely explore tool in drug candidate identification. In this study we used computational approached to identify 12 genes that are potential druggable candidate for curcumin. The genes identified were found to be enriched in cancer and drug resistance associated signaling pathways. Interestingly, the top 3 identified genes; Microtubule-associated protein tau (MAPT), Toll-like receptor 9 (TLR9) and Tyrosyl-DNA phosphodiesterase 1 (TDP1) were observed to be over expressed in multiple cancer cohorts and were associated with poor prognoses of the patients. Curcumin has good physicochemical, bioavailability and ADMET properties. Importantly, it met the Lipinski's Rule of 5 for drug likeness and thus worthy of further in vitro and in vivo confirmation studies.Item The Effects of Abandonment of Projects in Plateau State, Nigeria(International Journal of Engineering Research and Development, 2021) Alaezi, J.O.; Rugu, E.A.; Marut, J.J.; Igwe, C.O.Public Project particularly infrastructural projects are intended to provide new products and services to the community and at the same time promote the beauty of the environment however, their abandonment has led to so many negative effects. The study has determined the effects of abandonment of projects in plateau state, Nigeria. Quantitative method of data collection was employed in the study using close ended questionnaire. The data analysis tool that was employed for this study is the relative importance index (R.I.I). The RII was used to analyzed data obtained for the effects of abandonment of projects; the highest value of RII was ranked 1 and so on. Also descriptive statistics was employed to analyze the background of the respondents. It has been discovered from the research that, project abandonment has at least (15) far-reaching effects on national development. Cost overrun which was ranked first (1 ) with 91.00% is a very significant effect of project st abandonment, when projects are abandoned it leads to increase in the initial cost of the project, the final cost of the project will be exceeded leading to the initial cost of the project as a result of non-completion of projects within the agreed contract period. Other effects of project abandonment include: discouragement of investment is 89.00%, wastage of expended resources 88.00%, affects economic growth 86.00%, leads to unemployment 85.00%, hide out for criminals 83.00%, time overrun 82.00%, disappointment to the prospective users 81.00%, increase risk and project becomes obsolete and affects the aesthetics of the built environment 80.00%, affects quality 79.00% and reduces revenue 79.00%, technological backwardness 78.00% and finally reduces standard of living with 72.00%. It can be inferred that project abandonment has great effect on cost